sample preparation for thermal ionization mass spectrometer

US9779927B2 - Sample preparation and nanoelectrospray ,

This is a 371 of PCT/US2013/037138 filed 18 Apr 2013 (international filing date) This invention relates to a system for sample preparation, sample storage, and subsequent ionization and analysis by nanoelectrospray ionization mass spectrometry...

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Ultra-trace determination of 135Cs/137Cs isotopic ratio by ,

Various sample preparation methods are summarized and compared The mass spectrometric techniques emphasized herein are thermal ionization mass spectrometry (TIMS), inductively coupled plasma mass ....

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Best Mass Spectrometry Conferences | Proteomics ,

Imaging Mass Spectrometry is a technology that combines advanced analytical techniques for the analysis of biomedical Chromatography with spatial fidelity An effective approach for imaging biological specimens in this way utilizes Matrix-Assisted Laser Desorption Ionization Mass Spectrometry (MALDI MS) Briefly, molecules of interest are ....

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Plutonium determination in bioassay samples using ,

thermal ionization magnetic sector mass spectrometer This instrument had been upgraded to include a source turret that can hold up to 5 filaments to eliminate the need to break the vacuum between each sample The analytical signal for each sample was optimized by slowly heating the sample while monitoring m/z = 242...

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Sample Preparation Guides - Chemistry Department

2 DO make the sample as clean as possible Purity and amount are the two big determinants for getting good mass spectrometry results 3 DO work with volatile solvents and buffers Volatile buffers will pass through the mass spectrometer...

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MALDI (Matrix Assisted Laser Desorption Ionization)

The electrospray ion source is undoubtedly essential for mass spectrometry for application in biology, MALDI is also an essential and very effective tool in this field, along with electrospray ionization, is now among the most important ionization methods for high molecular weight compounds...

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Improved Sample Loading for Plutonium Analysis by Thermal ,

Thermal ionization mass spectrometry (TIMS) and alpha spectroscopy are , TIMS sample loading Substrate preparation involved forming ultrathin films (10-180 nm) of quaternary amine anion-exchange polymers on glass and silicon by dip-coating...

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Forensic applications of ambient ionization mass ,

ionization is principally by ion/molecule reactions with solvated hydronium ions and solvated hydroxyl anions Sample analysis in these desorption ionization experiments is performed in the native environment at atmospheric pressure without the requirement for sample confinement in the vacuum of the mass spectrometer Sample preparation...

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Thermal Ionization Mass Spectrometry (TIMS) - SERC

User's Guide - Sample Collection and Preparation , For more information about Thermal Ionization Mass Spectrometry (TIMS) follow the links below Thermal Ionization- this page, from the University of Arizona SAHRA program, offers a brief description of thermal ionization...

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Thermal Ionization Mass Spectrometry - an overview ,

Thermal Ionization Mass Spectrometry In Thermal Ionization Mass Spectrometry , (TIMS), a sample is deposited onto a metal filament, through which a current is passed to heat it to high temperatures inside the vacuum of the mass spectrometer...

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Mass Spectrometry - Molecular Characterization and ,

The Direct Sample Analysis (DSA) is a type of ambient ionization source Ambient mass spectrometry is classified by the ability to sample and ionize analytes directly from surfaces with little to no sample preparation...

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Ambient pressure thermal desorption ionization mass ,

This report presents one possible technique, ambient pressure thermal desorption ionization mass spectrometry, which could prove to be useful to the forensic science community Example mass spectra for several explosive compounds and illicit drugs obtained from liquid and bulk samples with almost no sample preparation are presented...

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Universal Sample Preparation Method for Characterization ,

Universal Sample Preparation Method for Characterization of Bacteria by Matrix-Assisted Laser Desorption Ionization-Time of , we developed a universal method for bacterial identification by matrix-assisted laser desorption ionization-time of flight mass spectrometry The effects on the mass spectrum of different experimental conditions ....

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Akio Makishima: Thermal ionization mass spectrometry (TIMS ,

The book Thermal ionization mass spectrometry (TIMS): silicate digestion, separation, and measurement by Akio Makishima discusses the entire process required to perform isotopic analyses by TIMS, including descriptions of initial sample digestion techniques for a variety of environmental and geological matrices, detailing chemical separations ....

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Thermal ionization mass spectrometry (TIMS): Thermo-Fisher ,

Thermal ionization mass spectrometry (TIMS): Thermo-Fisher Triton , Multiple clean-room facility equipped for all aspects of sample preparation SUPPORTING LABS: Optical microscopy lab, microsampling, rock room, , Mass spectrometer lab chief Tim Mock and staff scientist Richard Carlson discuss Nd isotope data...

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Thermal Ionization Mass Spectrometry (TIMS) | Wiley Online ,

In addition to thermal ionization mass spectrometry (TIMS), he also discusses applications of ICP-MS Furthermore, alongside detailed protocols on sample preparation and mass spectrometric measurements, numerous practical hints are given...

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Journal of Analytical Atomic Spectrometry - pubsrscorg

Ultra-trace determination of the 135 Cs/ 137 Cs isotopic ratio by thermal ionization mass spectrometry with application to Fukushima marine , A combination of single AMP-PAN column separation and ion exchange chromatography purification was used for sample preparation High separation factors (10 4 to 10 8) for the major matrix and ....

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SAHRA - Isotopes

Thermal Ionization: Thermal ionization mass spectrometry, or TIMS, has long been used as a standard method for very precise determination of isotope ratios in fields such as isotope geology , TIMS requires time-consuming sample preparation to ensure high quality chemical separation of the analyte It is also important to correct for isotopic ....

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PRACTICAL APPLICATION OF THERMAL IONIZATION MASS ,

Practical Application of Thermal Ionization Mass Spectrometry for the Determination of Plutonium for the LANL Bioassay Program , data in a timely fashion must be balanced with the historical routine performance of the RAS and TIMS operations of sample receipt, login, preparation,...

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Spark ionization - Wikipedia

When incorporated with a mass spectrometer the complete instrument is referred to as a spark ionization mass spectrometer or as a spark source mass spectrometer (SSMS) , Metals were a class of material that could not be previously ionized by thermal ionization (the method formerly used for ionizing solid sample) , Sample preparation...

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Thermal ionization mass spectrometry - Revolvy

Thermal ionization mass spectrometry (TIMS) is a highly sensitive isotope mass spectrometry characterization technique that exploits the thermal ionization effect, in which a chemically purified sample is heated to cause ionization of the atoms of the sample...

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Materials and Fuels Complex - Thermal Ionization Mass ,

Thermal Ionization Mass Spectrometer Home Currently selected; Facilities & Instruments; Staff Instrument Description TIMS is an analytical technique that requires the deposition of a sample onto a sample holder (filament in this case), whereafter the sample filament and ionizing filament are loaded into a carousel and placed into the ....

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An Efficient Sample Preparation Method to Enhance ,

Sample preparation is a critical process in mass spectrometry (MS) analysis of carbohydrat Although matrix-assisted laser desorption/ionization (MALDI) MS is the method of choice in carbohydrate analysis, poor ion signal and data reproducibility of carbohydrate samples continue to be severe problems...

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Field-portable mass spectrometers for onsite analytics ,

New ambient mass spectrometric methods (Cooks et al, 2006), in which ionization takes place both at atmospheric pressure and directly from the native sample without prior preparation, have rapidly been developed, and several interesting applications have come from their implementation...

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The Thermal Ionization Mass Spectrometer Lab at Duke ,

Methods Boron isotope methodology Sample preparation: Aqueous samples are loaded directly or preconcentrated via low-temperature, partial evaporation in oven in vertical laminar flow clean hood equipped with boron-free PTFE HEPA filtration Mass spectrometry:...

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Extraction Chromatographic Methods in the Sample ,

@article{osti_1032403, title = {Extraction Chromatographic Methods in the Sample Preparation Sequence for Thermal Ionization Mass Spectrometric Analysis of Plutonium Isotopes}, author = {Grate, Jay W and O'Hara, Matthew J and Farawila, Anne F and Douglas, Matthew and Haney, Morgan M and Peterson, Steve L and Maiti, Tapas C and Aardahl ....

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Mass spectrometry - Wikipedia

A mass spectrometer consists of three components: an ion source, a mass analyzer, and a detector The ionizer converts a portion of the sample into ions There is a wide variety of ionization techniques, depending on the phase (solid, liquid, gas) of the sample and the efficiency of various ionization mechanisms for the unknown speci...

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Extraction Chromatographic Methods in the Sample ,

A sample preparation sequence for actinide isotopic analysis by thermal ionization mass spectrometry (TIMS) is described that includes column-based extraction chromatography as the first separation step, followed by anion-exchange column separations...

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Sample preparation in mass spectrometry - Revolvy

Sample preparation for mass spectrometry is used for the optimization of a sample for analysis in a mass spectrometer (MS) Each ionization method has certain factors that must be considered for that method to be successful, such as volume, concentration , sample ,...

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Mass spectrometry | Britannica

Mass spectrometry: Mass spectrometry, analytic technique by which chemical substances are identified by the sorting of gaseous ions in electric and magnetic fields according to their mass-to-charge ratios , A disadvantage of thermal ionization is the possible change in isotopic composition during the measurement , Sample introduction The ....

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